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3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation
[Image: see text] Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is a validated and attractive target for cancer therapy. Overexpression of Mcl-1 in many cancers results in disease progression and resistance to current chemotherapeutics. Utilizing high-throughput screening, compound...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033665/ https://ncbi.nlm.nih.gov/pubmed/24749893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500010b |
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