Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening

Protein-protein interactions (PPIs) represent important and promising therapeutic targets that are associated with the regulation of various molecular pathways, particularly in cancer. Although they were once considered “undruggable,” the recent advances in screening strategies, structure-based desi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mady, Ahmed S. A., Liao, Chenzhong, Bajwa, Naval, Kump, Karson J., Abulwerdi, Fardokht A., Lev, Katherine L., Miao, Lei, Grigsby, Sierrah M., Perdih, Andrej, Stuckey, Jeanne A., Du, Yuhong, Fu, Haian, Nikolovska-Coleska, Zaneta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033896/
https://ncbi.nlm.nih.gov/pubmed/29976942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27899-9
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