Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins

Anti-apoptotic Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated therapeutic targets. Cancer cells display survival dependence on individual or subsets of anti-apoptotic proteins that could be effectively targeted by multimodal inhibitors. We design...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Kump, Karson J., Miao, Lei, Mady, Ahmed S.A., Ansari, Nurul H., Shrestha, Uttar K., Yang, Yuting, Pal, Mohan, Liao, Chenzhong, Perdih, Andrej, Abulwerdi, Fardokht A., Chinnaswamy, Krishnapriya, Meagher, Jennifer L., Carlson, Jacob M., Khanna, May, Stuckey, Jeanne A., Nikolovska-Coleska, Zaneta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024114/
https://ncbi.nlm.nih.gov/pubmed/31971799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01442
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