Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins

Anti-apoptotic Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated therapeutic targets. Cancer cells display survival dependence on individual or subsets of anti-apoptotic proteins that could be effectively targeted by multimodal inhibitors. We design...

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Vydáno v:J Med Chem
Hlavní autoři: Kump, Karson J., Miao, Lei, Mady, Ahmed S.A., Ansari, Nurul H., Shrestha, Uttar K., Yang, Yuting, Pal, Mohan, Liao, Chenzhong, Perdih, Andrej, Abulwerdi, Fardokht A., Chinnaswamy, Krishnapriya, Meagher, Jennifer L., Carlson, Jacob M., Khanna, May, Stuckey, Jeanne A., Nikolovska-Coleska, Zaneta
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024114/
https://ncbi.nlm.nih.gov/pubmed/31971799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01442
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