3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

[Image: see text] Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is a validated and attractive target for cancer therapy. Overexpression of Mcl-1 in many cancers results in disease progression and resistance to current chemotherapeutics. Utilizing high-throughput screening, compound...

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Detalhes bibliográficos
Main Authors: Abulwerdi, Fardokht A., Liao, Chenzhong, Mady, Ahmed S., Gavin, Jordan, Shen, Chenxi, Cierpicki, Tomasz, Stuckey, Jeanne A., Showalter, H. D. Hollis, Nikolovska-Coleska, Zaneta
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033665/
https://ncbi.nlm.nih.gov/pubmed/24749893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500010b
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