Wordt geladen...
3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation
[Image: see text] Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is a validated and attractive target for cancer therapy. Overexpression of Mcl-1 in many cancers results in disease progression and resistance to current chemotherapeutics. Utilizing high-throughput screening, compound...
Bewaard in:
| Hoofdauteurs: | , , , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2014
|
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033665/ https://ncbi.nlm.nih.gov/pubmed/24749893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500010b |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|