First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils

PURPOSE: Administration of therapeutic monoclonal antibodies (mAbs) is frequently accompanied by severe first infusion reactions (FIR). The mechanism driving FIR is still unclear. This study aimed to investigate the cellular and molecular mechanisms causing FIR in humanized mouse models and their po...

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Veröffentlicht in:Pharm Res
Hauptverfasser: Weber, Felix, Breustedt, Daniel, Schlicht, Sonja, Meyer, Claas A., Niewoehner, Jens, Ebeling, Martin, Freskgard, Per-Ola, Bruenker, Peter, Singer, Thomas, Reth, Michael, Iglesias, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021477/
https://ncbi.nlm.nih.gov/pubmed/29951887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2448-8
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