PHARMACOLOGICAL INHIBITION OF JAK2-STAT5 SIGNALING BY JAK2 INHIBITOR AZD1480 POTENTLY SUPPRESSES GROWTH OF BOTH PRIMARY AND CASTRATE-RESISTANT PROSTATE CANCER

PURPOSE: Progression of prostate cancer (PC) to the lethal castrate-resistant (CR) stage coincides with loss of responsiveness to androgen deprivation and requires development of novel therapies. We previously provided proof-of-concept that Stat5a/b is a therapeutic target protein for PC. Here we de...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Gu, Lei, Liao, Zhiyong, Hoang, David, Dagvadorj, Ayush, Gupta, Shilpa, Blackmon, Shauna, Ellsworth, Elyse, Talati, Pooja, Leiby, Benjamin, Zinda, Michael, Lallas, Costas D., Trabulsi, Edouard J., McCue, Peter, Gomella, Leonard, Huszar, Dennis, Nevalainen, Marja T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021137/
https://ncbi.nlm.nih.gov/pubmed/23942095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0422
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