Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer

Active Stat5a/b predicts early recurrence and disease-specific death in prostate cancer (PC), which both typically are caused by development of metastatic disease. Herein, we demonstrate that Stat5a/b induces epithelial-to-mesenchymal transition (EMT) of PC cells, as shown by Stat5a/b regulation of...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Talati, Pooja G., Gu, Lei, Ellsworth, Elyse M., Girondo, Melanie A., Trerotola, Marco, Hoang, David T., Leiby, Benjamin, Dagvadorj, Ayush, McCue, Peter A., Lallas, Costas D., Trabulsi, Edouard J., Gomella, Leonard, Aplin, Andrew E., Languino, Lucia, Fatatis, Alessandro, Rui, Hallgeir, Nevalainen, Marja T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2015
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597281/
https://ncbi.nlm.nih.gov/pubmed/26362718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.04.026
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