Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer

Active Stat5a/b predicts early recurrence and disease-specific death in prostate cancer (PC), which both typically are caused by development of metastatic disease. Herein, we demonstrate that Stat5a/b induces epithelial-to-mesenchymal transition (EMT) of PC cells, as shown by Stat5a/b regulation of...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Talati, Pooja G., Gu, Lei, Ellsworth, Elyse M., Girondo, Melanie A., Trerotola, Marco, Hoang, David T., Leiby, Benjamin, Dagvadorj, Ayush, McCue, Peter A., Lallas, Costas D., Trabulsi, Edouard J., Gomella, Leonard, Aplin, Andrew E., Languino, Lucia, Fatatis, Alessandro, Rui, Hallgeir, Nevalainen, Marja T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597281/
https://ncbi.nlm.nih.gov/pubmed/26362718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.04.026
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