Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer

Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate ca...

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Publié dans:Mol Cancer Ther
Auteurs principaux: Hoang, David T., Gu, Lei, Liao, Zhiyong, Talati, Pooja G., Shen, Feng, Koptyra, Mateusz, Tan, Shyh-Han, Ellsworth, Elyse, Gupta, Shilpa, Montie, Heather, Dagvadorj, Ayush, Savolainen, Saija, Leiby, Benjamin, Mirtti, Tuomas, Merry, Diane E., Nevalainen, Marja T.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456253/
https://ncbi.nlm.nih.gov/pubmed/25552366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0819
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