Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer

Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate ca...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Hoang, David T., Gu, Lei, Liao, Zhiyong, Talati, Pooja G., Shen, Feng, Koptyra, Mateusz, Tan, Shyh-Han, Ellsworth, Elyse, Gupta, Shilpa, Montie, Heather, Dagvadorj, Ayush, Savolainen, Saija, Leiby, Benjamin, Mirtti, Tuomas, Merry, Diane E., Nevalainen, Marja T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456253/
https://ncbi.nlm.nih.gov/pubmed/25552366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0819
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