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Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer

Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate ca...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cancer Ther
Main Authors: Hoang, David T., Gu, Lei, Liao, Zhiyong, Talati, Pooja G., Shen, Feng, Koptyra, Mateusz, Tan, Shyh-Han, Ellsworth, Elyse, Gupta, Shilpa, Montie, Heather, Dagvadorj, Ayush, Savolainen, Saija, Leiby, Benjamin, Mirtti, Tuomas, Merry, Diane E., Nevalainen, Marja T.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456253/
https://ncbi.nlm.nih.gov/pubmed/25552366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0819
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