Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer

Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate ca...

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Publicado en:Mol Cancer Ther
Autores principales: Hoang, David T., Gu, Lei, Liao, Zhiyong, Talati, Pooja G., Shen, Feng, Koptyra, Mateusz, Tan, Shyh-Han, Ellsworth, Elyse, Gupta, Shilpa, Montie, Heather, Dagvadorj, Ayush, Savolainen, Saija, Leiby, Benjamin, Mirtti, Tuomas, Merry, Diane E., Nevalainen, Marja T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456253/
https://ncbi.nlm.nih.gov/pubmed/25552366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0819
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