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Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

Transient receptor potential (TRP) channels are involved in various physiological processes, including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in epithelia and its expression is dramatically increased in numerous types of cancer. TRPV6 inhibitors suppress tumor growth, bu...

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書目詳細資料
發表在:Nat Commun
Main Authors: Singh, Appu K., Saotome, Kei, McGoldrick, Luke L., Sobolevsky, Alexander I.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018633/
https://ncbi.nlm.nih.gov/pubmed/29941865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04828-y
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