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Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

Transient receptor potential (TRP) channels are involved in various physiological processes, including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in epithelia and its expression is dramatically increased in numerous types of cancer. TRPV6 inhibitors suppress tumor growth, bu...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Singh, Appu K., Saotome, Kei, McGoldrick, Luke L., Sobolevsky, Alexander I.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018633/
https://ncbi.nlm.nih.gov/pubmed/29941865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04828-y
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