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Structure and Gating Mechanism of the Transient Receptor Potential Channel TRPV3

The transient receptor potential (TRP) channel TRPV3 plays a crucial role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with various skin diseases, including Olmsted syndrome, atopic dermatitis and rosacea. Here we present cryo-EM structures of full length mouse TRPV3 in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Struct Mol Biol
Main Authors: Singh, Appu K., McGoldrick, Luke L., Sobolevsky, Alexander I.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128766/
https://ncbi.nlm.nih.gov/pubmed/30127359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0108-7
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