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Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate

SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys, the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs) were associated with lower serum urate, further...

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Vydáno v:Front Physiol
Hlavní autoři: Ruiz, Anne, Gautschi, Ivan, Schild, Laurent, Bonny, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016318/
https://ncbi.nlm.nih.gov/pubmed/29967582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00476
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