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Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
BACKGROUND: Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function. Heterozygous GRN mutation carriers develop FTD with TDP-43 pathology and e...
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| Publicado en: | Mol Neurodegener |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6013889/ https://ncbi.nlm.nih.gov/pubmed/29929528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0264-6 |
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