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Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis

Flavin dependent halogenases (FDHs) catalyze the halogenation of organic substrates by coordinating reactions of reduced flavin, molecular oxygen, and chloride. Targeted and random mutagenesis of these enzymes has been used to both understand and alter their reactivity. These studies have led to ins...

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Detalles Bibliográficos
Publicado en:Annu Rev Biochem
Main Authors: Andorfer, Mary C., Lewis, Jared C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013374/
https://ncbi.nlm.nih.gov/pubmed/29589959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-062917-012042
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