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Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis

Flavin dependent halogenases (FDHs) catalyze the halogenation of organic substrates by coordinating reactions of reduced flavin, molecular oxygen, and chloride. Targeted and random mutagenesis of these enzymes has been used to both understand and alter their reactivity. These studies have led to ins...

詳細記述

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書誌詳細
出版年:Annu Rev Biochem
主要な著者: Andorfer, Mary C., Lewis, Jared C.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013374/
https://ncbi.nlm.nih.gov/pubmed/29589959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-062917-012042
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