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Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis
Flavin dependent halogenases (FDHs) catalyze the halogenation of organic substrates by coordinating reactions of reduced flavin, molecular oxygen, and chloride. Targeted and random mutagenesis of these enzymes has been used to both understand and alter their reactivity. These studies have led to ins...
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| Vydáno v: | Annu Rev Biochem |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6013374/ https://ncbi.nlm.nih.gov/pubmed/29589959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-062917-012042 |
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