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Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling

The activity of four native FDHs and four engineered FDH variants on 93 low molecular weight arenes was used to generate FDH substrate activity profiles. These profiles provided insights into how substrate class, functional group substitution, electronic activation, and binding impact FDH activity a...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Andorfer, Mary C., Grob, Jonathan E., Hajdin, Christine E., Chael, Julia R., Siuti, Piro, Lilly, Jeremiah, Tan, Kian L., Lewis, Jared C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627516/
https://ncbi.nlm.nih.gov/pubmed/28989809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.6b02707
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