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Predicting the Substrate Scope of the Flavin‐Dependent Halogenase BrvH

The recently described flavin‐dependent halogenase BrvH is able to catalyse both the bromination and chlorination of indole, but shows significantly higher bromination activity. BrvH was annotated as a tryptophan halogenase, but does not accept tryptophan as a substrate. Its native substrate remains...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem
Hauptverfasser: Neubauer, Pia R., Pienkny, Silke, Wessjohann, Ludger, Brandt, Wolfgang, Sewald, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754283/
https://ncbi.nlm.nih.gov/pubmed/32645255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000444
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