Glioblastoma-targeted CD4(+) CAR T cells mediate superior antitumor activity

Chimeric antigen receptor–modified (CAR-modified) T cells have shown promising therapeutic effects for hematological malignancies, yet limited and inconsistent efficacy against solid tumors. The refinement of CAR therapy requires an understanding of the optimal characteristics of the cellular produc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wang, Dongrui, Aguilar, Brenda, Starr, Renate, Alizadeh, Darya, Brito, Alfonso, Sarkissian, Aniee, Ostberg, Julie R., Forman, Stephen J., Brown, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012522/
https://ncbi.nlm.nih.gov/pubmed/29769444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99048
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