Glioblastoma-targeted CD4(+) CAR T cells mediate superior antitumor activity

Chimeric antigen receptor–modified (CAR-modified) T cells have shown promising therapeutic effects for hematological malignancies, yet limited and inconsistent efficacy against solid tumors. The refinement of CAR therapy requires an understanding of the optimal characteristics of the cellular produc...

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Publicat a:JCI Insight
Autors principals: Wang, Dongrui, Aguilar, Brenda, Starr, Renate, Alizadeh, Darya, Brito, Alfonso, Sarkissian, Aniee, Ostberg, Julie R., Forman, Stephen J., Brown, Christine E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012522/
https://ncbi.nlm.nih.gov/pubmed/29769444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99048
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