Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To achieve broader and more effective GBM targeting, we developed a peptide-bearing CAR exploiting the GBM-binding potential of...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wang, Dongrui, Starr, Renate, Chang, Wen-Chung, Aguilar, Brenda, Alizadeh, Darya, Wright, Sarah L., Yang, Xin, Brito, Alfonso, Sarkissian, Aniee, Ostberg, Julie R., Li, Li, Shi, Yanhong, Gutova, Margarita, Aboody, Karen, Badie, Behnam, Forman, Stephen J., Barish, Michael E., Brown, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500824/
https://ncbi.nlm.nih.gov/pubmed/32132216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2672
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