Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To achieve broader and more effective GBM targeting, we developed a peptide-bearing CAR exploiting the GBM-binding potential of...

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Dades bibliogràfiques
Publicat a:Sci Transl Med
Autors principals: Wang, Dongrui, Starr, Renate, Chang, Wen-Chung, Aguilar, Brenda, Alizadeh, Darya, Wright, Sarah L., Yang, Xin, Brito, Alfonso, Sarkissian, Aniee, Ostberg, Julie R., Li, Li, Shi, Yanhong, Gutova, Margarita, Aboody, Karen, Badie, Behnam, Forman, Stephen J., Barish, Michael E., Brown, Christine E.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500824/
https://ncbi.nlm.nih.gov/pubmed/32132216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2672
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