Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells

Exhausted CD8 T cells (Tex) are immunotherapy targets in chronic infection and cancer, but a comprehensive assessment of Tex cell diversity in human disease is lacking. Here we developed a transcriptomic- and epigenetic-guided mass cytometry approach to define core exhaustion-specific genes and dise...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Bengsch, Bertram, Ohtani, Takuya, Khan, Omar, Setty, Manu, Manne, Sasikanth, O’Brien, Shaun, Gherardini, Pier Federico, Herati, Ramin Sedaghat, Huang, Alexander C., Chang, Kyong-Mi, Newell, Evan W., Bovenschen, Niels, Pe’er, Dana, Albelda, Steven M., Wherry, E. John
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010198/
https://ncbi.nlm.nih.gov/pubmed/29768164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.026
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