Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: D’Ascenzio, Melissa, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, Florio, Rosalba, Mollica, Adriano, Ceruso, Mariangela, Akdemir, Atilla, Sobolev, Anatoly P., Supuran, Claudiu T.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009879/
https://ncbi.nlm.nih.gov/pubmed/27784170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1235040
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires