Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs...

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Hlavní autoři: Morkūnaitė, Vaida, Baranauskienė, Lina, Zubrienė, Asta, Kairys, Visvaldas, Ivanova, Jekaterina, Trapencieris, Pēteris, Matulis, Daumantas
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168026/
https://ncbi.nlm.nih.gov/pubmed/25276805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/638902
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