Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs...

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Détails bibliographiques
Auteurs principaux: Morkūnaitė, Vaida, Baranauskienė, Lina, Zubrienė, Asta, Kairys, Visvaldas, Ivanova, Jekaterina, Trapencieris, Pēteris, Matulis, Daumantas
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168026/
https://ncbi.nlm.nih.gov/pubmed/25276805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/638902
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