Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

A key part of the optimization of small molecules in pharmaceutical inhibitor development is to vary the molecular design to enhance complementarity of chemical features of the compound with the positioning of amino acids in the active site of a target enzyme. Typically this involves iterations of s...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Smirnovienė, Joana, Smirnov, Alexey, Zakšauskas, Audrius, Zubrienė, Asta, Petrauskas, Vytautas, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Čapkauskaitė, Edita, Manakova, Elena, Gražulis, Saulius, Baranauskienė, Lina, Chen, Wen‐Yih, Ladbury, John E., Matulis, Daumantas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095314/
https://ncbi.nlm.nih.gov/pubmed/33945229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.202100042
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