Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

A key part of the optimization of small molecules in pharmaceutical inhibitor development is to vary the molecular design to enhance complementarity of chemical features of the compound with the positioning of amino acids in the active site of a target enzyme. Typically this involves iterations of s...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ChemistryOpen
Egile Nagusiak: Smirnovienė, Joana, Smirnov, Alexey, Zakšauskas, Audrius, Zubrienė, Asta, Petrauskas, Vytautas, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Čapkauskaitė, Edita, Manakova, Elena, Gražulis, Saulius, Baranauskienė, Lina, Chen, Wen‐Yih, Ladbury, John E., Matulis, Daumantas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2021
Gaiak:
Full Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095314/
https://ncbi.nlm.nih.gov/pubmed/33945229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.202100042
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