Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: D’Ascenzio, Melissa, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, Florio, Rosalba, Mollica, Adriano, Ceruso, Mariangela, Akdemir, Atilla, Sobolev, Anatoly P., Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009879/
https://ncbi.nlm.nih.gov/pubmed/27784170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1235040
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