Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold modification have been attempted on both saccharin a...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Guglielmi, Paolo, Rotondi, Giulia, Secci, Daniela, Angeli, Andrea, Chimenti, Paola, Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Carradori, Simone, Supuran, Claudiu T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580763/
https://ncbi.nlm.nih.gov/pubmed/33003975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1828401
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