The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with K(I)s of 260 and 57 nM,...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Pustenko, Aleksandrs, Nocentini, Alessio, Gratteri, Paola, Bonardi, Alessandro, Vozny, Igor, Žalubovskis, Raivis, Supuran, Claudiu T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178874/
https://ncbi.nlm.nih.gov/pubmed/32297543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1752201
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