The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with K(I)s of 260 and 57 nM,...

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Foilsithe in:J Enzyme Inhib Med Chem
Main Authors: Pustenko, Aleksandrs, Nocentini, Alessio, Gratteri, Paola, Bonardi, Alessandro, Vozny, Igor, Žalubovskis, Raivis, Supuran, Claudiu T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2020
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178874/
https://ncbi.nlm.nih.gov/pubmed/32297543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1752201
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