The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with K(I)s of 260 and 57 nM,...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Pustenko, Aleksandrs, Nocentini, Alessio, Gratteri, Paola, Bonardi, Alessandro, Vozny, Igor, Žalubovskis, Raivis, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178874/
https://ncbi.nlm.nih.gov/pubmed/32297543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1752201
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