Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

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Dettagli Bibliografici
Pubblicato in:J Enzyme Inhib Med Chem
Autori principali: D’Ascenzio, Melissa, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, Florio, Rosalba, Mollica, Adriano, Ceruso, Mariangela, Akdemir, Atilla, Sobolev, Anatoly P., Supuran, Claudiu T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009879/
https://ncbi.nlm.nih.gov/pubmed/27784170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1235040
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