Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1

Human flap endonuclease-1 (hFEN1) catalyzes the divalent metal ion-dependent removal of single-stranded DNA protrusions known as flaps during DNA replication and repair. Substrate selectivity involves passage of the 5′-terminus/flap through the arch and recognition of a single nucleotide 3′-flap by...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Bennet, Ian A, Finger, L David, Baxter, Nicola J, Ambrose, Benjamin, Hounslow, Andrea M, Thompson, Mark J, Exell, Jack C, Shahari, Nur Nazihah B Md, Craggs, Timothy D, Waltho, Jonathan P, Grasby, Jane A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009646/
https://ncbi.nlm.nih.gov/pubmed/29718417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky293
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