Observation of unpaired substrate DNA in the flap endonuclease-1 active site

The structure- and strand-specific phosphodiesterase flap endonuclease-1 (FEN1), the prototypical 5′-nuclease, catalyzes the essential removal of 5′-single-stranded flaps during replication and repair. FEN1 achieves this by selectively catalyzing hydrolysis one nucleotide into the duplex region of s...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: David Finger, L., Patel, Nikesh, Beddows, Amanda, Ma, Long, Exell, Jack C., Jardine, Emma, Jones, Anita C., Grasby, Jane A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834815/
https://ncbi.nlm.nih.gov/pubmed/23975198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt737
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi