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Observation of unpaired substrate DNA in the flap endonuclease-1 active site
The structure- and strand-specific phosphodiesterase flap endonuclease-1 (FEN1), the prototypical 5′-nuclease, catalyzes the essential removal of 5′-single-stranded flaps during replication and repair. FEN1 achieves this by selectively catalyzing hydrolysis one nucleotide into the duplex region of s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834815/ https://ncbi.nlm.nih.gov/pubmed/23975198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt737 |
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