Observation of unpaired substrate DNA in the flap endonuclease-1 active site

The structure- and strand-specific phosphodiesterase flap endonuclease-1 (FEN1), the prototypical 5′-nuclease, catalyzes the essential removal of 5′-single-stranded flaps during replication and repair. FEN1 achieves this by selectively catalyzing hydrolysis one nucleotide into the duplex region of s...

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Main Authors: David Finger, L., Patel, Nikesh, Beddows, Amanda, Ma, Long, Exell, Jack C., Jardine, Emma, Jones, Anita C., Grasby, Jane A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2013
Ábhair:
Nucleic Acid Enzymes
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834815/
https://ncbi.nlm.nih.gov/pubmed/23975198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt737
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