Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

Flap endonucleases (FENs), essential for DNA replication and repair, recognize and remove RNA or DNA 5′-flaps. Related to FEN specificity for substrates with free 5′-ends, but controversial, is the role of the helical arch observed in varying conformations in substrate-free FEN structures. Conflicti...

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Detalhes bibliográficos
Main Authors: Patel, Nikesh, Atack, John M., Finger, L. David, Exell, Jack C., Thompson, Peter, Tsutakawa, Susan, Tainer, John A., Williams, David M., Grasby, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378889/
https://ncbi.nlm.nih.gov/pubmed/22319208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks051
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