Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease

Protein nucleases and RNA enzymes depend on divalent metal ions to catalyze the rapid hydrolysis of phosphate diester linkages of nucleic acids during DNA replication, DNA repair, RNA processing, and RNA degradation. These enzymes are widely proposed to catalyze phosphate diester hydrolysis using a...

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Detalhes bibliográficos
Main Authors: Syson, Karl, Tomlinson, Christopher, Chapados, Brian R., Sayers, Jon R., Tainer, John A., Williams, Nicholas H., Grasby, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568906/
https://ncbi.nlm.nih.gov/pubmed/18697748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801264200
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