Human Replication Factor C Stimulates Flap Endonuclease 1

Flap endonuclease 1 (FEN1) is the enzyme responsible for specifically removing the flap structure produced during DNA replication, repair, and recombination. Here we report that the human replication factor C (RFC) complex stimulates the nuclease activity of human FEN1 in an ATP-independent manner....

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Detalhes bibliográficos
Main Authors: Cho, Il-taeg, Kim, Do-hyung, Kang, Young-Hoon, Lee, Chul-Hwan, Amangyelid, Tamir, Nguyen, Tuan Anh, Hurwitz, Jerard, Seo, Yeon-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667726/
https://ncbi.nlm.nih.gov/pubmed/19208620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808893200
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