DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction

Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes. hFEN1 biological function must be precisely controlled, and consequently, the protein relies on a combination of protein and substrate conforma...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Algasaier, Sana I., Exell, Jack C., Bennet, Ian A., Thompson, Mark J., Gotham, Victoria J. B., Shaw, Steven J., Craggs, Timothy D., Finger, L. David, Grasby, Jane A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825025/
https://ncbi.nlm.nih.gov/pubmed/26884332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698993
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