The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

Flap endonuclease 1 (FEN1) proteins, which are present in all kingdoms of life, catalyze the sequence-independent hydrolysis of the bifurcated nucleic acid intermediates formed during DNA replication and repair. How FEN1s have evolved to preferentially cleave flap structures is of great interest esp...

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Autors principals: David Finger, L., Blanchard, M. Suzette, Theimer, Carla A., Sengerová, Blanka, Singh, Purnima, Chavez, Valerie, Liu, Fei, Grasby, Jane A., Shen, Binghui
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755943/
https://ncbi.nlm.nih.gov/pubmed/19525235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015065
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