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Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation
Munc13-1 is a presynaptic active-zone protein essential for neurotransmitter release and presynaptic plasticity in the brain. This multidomain scaffold protein contains a C1 domain that binds to the activator diacylglycerol/phorbol ester. Although the C1 domain bears close structural homology with t...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008642/ https://ncbi.nlm.nih.gov/pubmed/29244485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00764 |
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