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The presynaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila
Munc13-1 is a presynaptic active-zone protein essential for neurotransmitter release and involved in presynaptic plasticity in brain. Ethanol, butanol and octanol quenched the intrinsic fluorescence of the C1 domain of Munc13-1 with EC(50)s of 52 mM, 26 mM and 0.7 mM, respectively. Photoactive azial...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3766433/ https://ncbi.nlm.nih.gov/pubmed/23692447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12315 |
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