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The presynaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila

Munc13-1 is a presynaptic active-zone protein essential for neurotransmitter release and involved in presynaptic plasticity in brain. Ethanol, butanol and octanol quenched the intrinsic fluorescence of the C1 domain of Munc13-1 with EC(50)s of 52 mM, 26 mM and 0.7 mM, respectively. Photoactive azial...

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Autors principals: Das, Joydip, Xu, Shiyu, Pany, Satyabrata, Guillory, Ashley, Shah, Vrutant, Roman, Gregg W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766433/
https://ncbi.nlm.nih.gov/pubmed/23692447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12315
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