Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase

Thymine DNA glycosylase (TDG) excises thymine from mutagenic G·T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5−formylcytosine (fC) and 5−carboxylcytosine (caC), in a multistep pathway for DNA demethylation. TDG is modified by small ubiquitin-like mod...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Coey, Christopher T, Drohat, Alexander C
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007377/
https://ncbi.nlm.nih.gov/pubmed/29660017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky278
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