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Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs

Repair of G·T mismatches arising from deamination of 5-methylcytosine (m(5)C) involves excision of thymine and restoration of a G·C pair via base excision repair (BER). Thymine DNA glycosylase (TDG) is one of two mammalian enzymes that can specifically remove thymine from G·T mispairs. While TDG can...

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Detalhes bibliográficos
Main Authors: Maiti, Atanu, Drohat, Alexander C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084331/
https://ncbi.nlm.nih.gov/pubmed/21474392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.03.004
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