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Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition
Cytosine methylation at CpG dinucleotides produces m(5)CpG, an epigenetic modification that is important for transcriptional regulation and genomic stability in vertebrate cells. However, m(5)C deamination yields mutagenic G·T mispairs, which are implicated in genetic disease, cancer, and aging. Hum...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2449336/ https://ncbi.nlm.nih.gov/pubmed/18587051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711061105 |
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