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Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA
Deamination of 5-methylcytosine to thymine creates mutagenic G·T mispairs, contributing to cancer and genetic disease. Thymine DNA glycosylase (TDG) removes thymine from these G·T lesions, and follow-on base excision repair yields a G·C pair. A previous crystal structure revealed TDG (catalytic doma...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064789/ https://ncbi.nlm.nih.gov/pubmed/21097883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1164 |
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