Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase

Thymine DNA glycosylase (TDG) is a base excision repair enzyme with key functions in epige-netic regulation. Performing a critical step in a pathway for active DNA demethylation, TDG removes 5-formylcytosine and 5-carboxylcytosine, oxidized derivatives of 5-methylcytosine that are generated by TET (...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Pidugu, Lakshmi S., Flowers, Joshua W., Coey, Christopher T., Pozharski, Edwin, Greenberg, Marc M., Drohat, Alexander C.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148694/
https://ncbi.nlm.nih.gov/pubmed/27805810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00982
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