Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G·T mispairs arising from deamination of 5-methylcytosine (mC), and it processes other deamination-derived lesions including uracil (U). Essential fo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Coey, Christopher T., Malik, Shuja S., Pidugu, Lakshmi S., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137436/
https://ncbi.nlm.nih.gov/pubmed/27580719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw768
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