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Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase
Thymine DNA glycosylase (TDG) is a base excision repair enzyme with key functions in epige-netic regulation. Performing a critical step in a pathway for active DNA demethylation, TDG removes 5-formylcytosine and 5-carboxylcytosine, oxidized derivatives of 5-methylcytosine that are generated by TET (...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5148694/ https://ncbi.nlm.nih.gov/pubmed/27805810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00982 |
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